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Impact of Substance Use Disorder on Between-Network Brain Connectivity in Early Psychosis
Psychotic disorders involve brain network dysconnectivity, with abnormalities in salience, default mode, and central executive networks. Substance use may worsen these connectivity issues and influence symptom severity.
Advances in neuroimaging studies of Alcohol Use Disorder (AUD)
Neuroimaging reveals alcohol use disorder (AUD) patients experience reduced gray matter volume, especially in frontal brain regions, and significant white matter changes. Abstinence can partially reverse these brain deficits.
Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review
Psychedelic drugs show promise for treating mental disorders, including depression and addiction. Research is exploring how these substances affect the brain and mind at different levels to understand their therapeutic potential.
Psychedelics and health behaviour change
Psychedelic compounds are being explored as tools to promote healthier lifestyles and treat various conditions. Research from past decades and renewed 21st-century studies show promising results for treating mood disorders and addictions.
Adverse effects of psychedelics: From anecdotes and misinformation to systematic science
Psychedelic medicines are gaining attention for medical use, leading to regulatory changes in the US and Canada. This review examines potential risks, aiming to distinguish facts from misinformation.
Associations between cannabis use, Cannabis Use Disorder, and mood disorders: Longitudinal, genetic, and neurocognitive evidence
Cannabis use is widespread, and rates of use in individuals with depression are increasing faster than in non-depressed individuals. Many report using cannabis to alleviate mood disorder symptoms, but it can also worsen them.
Synaptic changes induced by cannabinoid drugs and Cannabis Use Disorder
Cannabis use is widespread and increasingly popular, despite risks like dependence and withdrawal. While behavioral effects are known, the underlying neurobiological mechanisms are still being explored.
Thalamocortical functional connectivity and cannabis use in men with childhood Attention-Deficit/Hyperactivity Disorder
ADHD symptoms often persist into adulthood, increasing the risk of substance use disorder, including cannabis use. Brain regions like the thalamus may play a role in this increased risk.
Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
Early childhood trauma, especially maltreatment, often leads to PTSD in youth. This trauma significantly increases the risk of developing substance use disorders, creating a complex cycle of challenges.
Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review
This document systematically reviews adverse events reported during or after psychedelic treatments for mental disorders. It identifies challenges in assessing these events due to varied reporting and terminology.
MDMA and memory, addiction, and depression: dose-effect analysis
MDMA shows promise as a psychotherapeutic agent due to its ability to increase empathy and sociality.
Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail
Drug and alcohol dependence is a serious global issue. Current treatments for opioid dependence vary in effectiveness, and there are no consistently effective treatments for methamphetamine use disorder.
Polysubstance Use Plays a Key Role in Midlife Structural Brain Alterations in Long-term Cannabis Users
A study found long-term cannabis users had older brain ages and thinner brain regions. However, these effects were no longer significant when accounting for long-term use of other drugs like tobacco and alcohol.
Latent patterns of polysubstance use among people who use opioids: A systematic review
Polysubstance use (PSU) is common among people who use opioids, yet its definition and measurement vary. This review classifies and describes these patterns to help inform overdose prevention and harm reduction.
Specific polysubstance use patterns predict relapse among patients entering Opioid Use Disorder treatment
This study found that polysubstance use is common among people with opioid use disorder. It explored daily drug use patterns before treatment, revealing subgroups of polysubstance use that may predict relapse.