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Synaptic changes induced by cannabinoid drugs and Cannabis Use Disorder
Cannabis use is widespread and increasingly popular, despite risks like dependence and withdrawal. While behavioral effects are known, the underlying neurobiological mechanisms are still being explored.
Thalamocortical functional connectivity and cannabis use in men with childhood Attention-Deficit/Hyperactivity Disorder
ADHD symptoms often persist into adulthood, increasing the risk of substance use disorder, including cannabis use. Brain regions like the thalamus may play a role in this increased risk.
Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders
Early childhood trauma, especially maltreatment, often leads to PTSD in youth. This trauma significantly increases the risk of developing substance use disorders, creating a complex cycle of challenges.
Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review
This document systematically reviews adverse events reported during or after psychedelic treatments for mental disorders. It identifies challenges in assessing these events due to varied reporting and terminology.
MDMA and memory, addiction, and depression: dose-effect analysis
MDMA shows promise as a psychotherapeutic agent due to its ability to increase empathy and sociality.
Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail
Drug and alcohol dependence is a serious global issue. Current treatments for opioid dependence vary in effectiveness, and there are no consistently effective treatments for methamphetamine use disorder.
Polysubstance Use Plays a Key Role in Midlife Structural Brain Alterations in Long-term Cannabis Users
A study found long-term cannabis users had older brain ages and thinner brain regions. However, these effects were no longer significant when accounting for long-term use of other drugs like tobacco and alcohol.
Latent patterns of polysubstance use among people who use opioids: A systematic review
Polysubstance use (PSU) is common among people who use opioids, yet its definition and measurement vary. This review classifies and describes these patterns to help inform overdose prevention and harm reduction.
Specific polysubstance use patterns predict relapse among patients entering Opioid Use Disorder treatment
This study found that polysubstance use is common among people with opioid use disorder. It explored daily drug use patterns before treatment, revealing subgroups of polysubstance use that may predict relapse.
Polysubstance Use in Early Adulthood: Patterns and Developmental Precursors in an Urban Cohort
This study investigated the prevalence and patterns of polysubstance use from adolescence to early adulthood. It also identified childhood risk factors predicting different types of polysubstance use in young adulthood.
Adolescence is a Sensitive Period for Prefrontal Microglia to Act on Cognitive Development
Depleting prefrontal microglia in adolescent mice caused lasting changes in the prefrontal cortex's cognitive functions and synaptic structures. These findings highlight microglia's role in brain maturation.
Alcohol and the Adolescent Brain: What We’ve Learned and Where the Data are Taking Us
Adolescent alcohol use, especially binge drinking, is a major public health concern. Research highlights how alcohol impacts the still-developing teenage brain, increasing risks for negative health and social outcomes.
Brain network dysfunctions in addiction: A meta-analysis of resting-state functional connectivity
Substance use and behavioral addictions share symptoms like compulsive behavior and loss of control. This study will compare brain activity in different addictions to understand their unique features and shared origins.
Contextualizing Adolescent Structural Brain Development: Environmental Determinants and Mental Health Outcomes
Brain development continues throughout adolescence, with gray matter decreasing and white matter increasing. Environmental factors and individual differences also shape this development, influencing well-being and mental health.
Drugs, Guts, Brains, but Not Rock and Roll: The Need to Consider the Role of Gut Microbiota in Contemporary Mental Health and Wellness of Emerging Adults
Emerging adults aged 18-25 show unique gut microbiome vulnerability, which influences their mental health due to brain development and stress responses. This period is crucial for interventions to promote long-term well-being.