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Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder
Alcohol use disorder is often undertreated. New and existing medications show promise for future treatment, including personalized approaches for diverse patient needs.
Gene-based polygenic risk scores analysis of Alcohol Use Disorder in African Americans
This study proposes a new gene-based method to improve genetic risk prediction for alcohol use disorder in diverse populations. It focuses on shared disease-causing genes between different ancestries.
Alcohol Use Disorder in the COVID-19 era: Position paper of the Italian Society on Alcohol (SIA)
The Italian Society of Alcohology (ISA) developed guidelines for managing alcohol use disorder (AUD) in COVID-19 patients. This addresses increased AUD during lockdowns and the unique challenges posed by co-occurring COVID-19 infection.
Understanding Stimulant Use and Use Disorders in a New Era
Drug overdose deaths are rising due to illicit opioids, stimulants like methamphetamine and cocaine, and their co-use. This "fourth wave" of mortality is driven by increased supply and potency of these substances.
The Developmental Origins of Opioid Use Disorder and Its Comorbidities
Early life adversity can disrupt the brain's reward system, increasing the risk for opioid use disorder and co-occurring mental health issues like depression. This impact can differ between biological sexes.
Impulsive trait mediates the relationship between white matter integrity of prefrontal-striatal circuits and the severity of dependence in alcoholism
Alcohol dependence is a chronic relapsing disease that impairs control over drinking despite negative consequences. Impulsivity increases relapse risk due to weakened brain pathways controlling inhibition.
Enduring disruption of reward and stress circuit activities by early-life adversity in male rats
Early-life adversity in male rats leads to a reduced response to opioid rewards, suggesting a form of anhedonia for these drugs. This blunted behavior may involve altered brain activation in reward and stress circuits.
Addiction Treatment and Telehealth: Review of Efficacy and Provider Insights During the COVID-19 Pandemic
Telehealth for addiction treatment shows similar outcomes to in-person care for retention and satisfaction. Providers believe it improves access and works best for individual counseling.
Consideration of sex and gender differences in addiction medication response
Research shows sex and gender are often overlooked in addiction medication development. This can lead to different treatment responses between men and women, impacting care for substance use disorders.
An unknown invisible intrusion. Impact of an adult family member’s problematic substance use on family life: a meta-ethnography
Problematic substance use significantly harms both individuals and their families. While the user's struggles are acknowledged, the profound, far-reaching impact on close family members often goes unaddressed.
School Health Predictors of the School-to-Prison Pipeline: Substance Use and Developmental Risk and Resilience Factors
This study found that student substance use and other risk factors in schools predict school discipline and police contact. These outcomes are key components of the "school-to-prison pipeline."
Addressing adolescent substance use with a public health prevention framework: The case for harm reduction
Harm reduction principles should be integrated with traditional prevention for adolescents with problematic substance use. This approach can help minimize negative health and social impacts.
Association between contact with mental health and substance use services and reincarceration after release from prison
A study found that people receiving mental health or substance use services after prison release had a lower risk of re-incarceration. However, consistent engagement with these services improved outcomes more.
PriSUD-Nordic—Diagnosing and Treating Substance Use Disorders in the Prison Population: Protocol for a Mixed Methods Study
This project examines substance use disorders in Nordic prisons across three periods: before, during, and after imprisonment. It combines extensive registry data with qualitative research to understand this vulnerable population.
Perspectives of Adults with Disabilities and Opioid Misuse: Qualitative Findings Illuminating Experiences with Stigma and Substance Use Treatment
Adults with disabilities are more likely to misuse prescription opioids and experience opioid use disorders. They face unique barriers to treatment, including stigma and inaccessible care, compounded by their other identities.