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MDMA and memory, addiction, and depression: dose-effect analysis
MDMA shows promise as a psychotherapeutic agent due to its ability to increase empathy and sociality.
Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail
Drug and alcohol dependence is a serious global issue. Current treatments for opioid dependence vary in effectiveness, and there are no consistently effective treatments for methamphetamine use disorder.
Polysubstance Use Plays a Key Role in Midlife Structural Brain Alterations in Long-term Cannabis Users
A study found long-term cannabis users had older brain ages and thinner brain regions. However, these effects were no longer significant when accounting for long-term use of other drugs like tobacco and alcohol.
Latent patterns of polysubstance use among people who use opioids: A systematic review
Polysubstance use (PSU) is common among people who use opioids, yet its definition and measurement vary. This review classifies and describes these patterns to help inform overdose prevention and harm reduction.
Specific polysubstance use patterns predict relapse among patients entering Opioid Use Disorder treatment
This study found that polysubstance use is common among people with opioid use disorder. It explored daily drug use patterns before treatment, revealing subgroups of polysubstance use that may predict relapse.
Polysubstance Use in Early Adulthood: Patterns and Developmental Precursors in an Urban Cohort
This study investigated the prevalence and patterns of polysubstance use from adolescence to early adulthood. It also identified childhood risk factors predicting different types of polysubstance use in young adulthood.
Brain network dysfunctions in addiction: A meta-analysis of resting-state functional connectivity
Substance use and behavioral addictions share symptoms like compulsive behavior and loss of control. This study will compare brain activity in different addictions to understand their unique features and shared origins.
Vulnerability to addiction
The DSM's definition of addiction has evolved from physical symptoms to a behavioral-centered, dimensional approach. Animal models use behavioral hallmarks like persistence and motivation to study addiction's neurobiology.
Social vulnerabilities for substance use: Stressors, socially toxic environments, and discrimination and racism
Social stressors significantly increase vulnerability to substance use disorders. Factors like poverty and discrimination contribute to chronic stress, impacting health and increasing substance misuse risk.
Addiction as a brain disease revised: Why it still matters, and the need for consilience
The "addiction as a brain disease" concept, while influential, faces scientific criticism. This summary addresses these critiques, arguing that refining the original postulates can improve patient care and treatment development.
Heroin addiction hijacks the Nucleus Accumbens: Craving and reactivity to naturalistic stimuli
Heroin users' brains showed heightened responses to drug-related content in a movie. This activity was linked to craving, suggesting specific brain areas are key to addiction.
The impact of Substance Use Disorder on COVID-19 outcomes
A study of over 11,000 adults with COVID-19 found substance use disorders linked to increased hospitalization, ventilator use, and death. These risks may be partly due to drug-related respiratory and cardiovascular diseases.
The molecular neurobiology and neuropathology of opioid use disorder
Opioid use disorder is a chronic condition driven by brain changes, causing compulsive drug taking and cravings. The widespread misuse of opioids has led to significant health and financial crises globally.
Drug addiction: From bench to bedside
Drug addiction causes 11.8 million deaths annually, surpassing cancer deaths. It is a chronic, relapsing brain disease shaped by biological, behavioral, and social factors. Effective treatment requires a personalized approach.
Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis
Substance use disorders (SUDs) are a major public health issue affecting millions worldwide. SUDs cause brain changes that can be observed with MRI, but the specific regions affected vary by substance and individual.