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Trauma and Post-Traumatic Stress Disorder in Patients Treated for Opioid Use Disorder: Findings From a 12-Month Cohort Study
This study found that 11% of opioid use disorder patients had PTSD, and nearly half reported past trauma. Those with PTSD were more often female and less likely to be employed or married.
Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings
Early life stress, like abuse or neglect, affects millions of children and increases health risks. This trauma is linked to a higher chance of developing opioid use disorder later in life.
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
Psychedelics like psilocybin and LSD alter mood and cognition by affecting serotonin receptors. These compounds are physiologically safe and induce changes in neuroplasticity, which underlies their lasting psychological effects.
Psychedelics and Other Psychoplastogens for Treating Mental Illness
The article explains that the long-held "chemical imbalance" theory of depression is oversimplified. Instead, depression may stem from issues with brain circuitry, which new "psychoplastogen" treatments could help fix.
Neurotoxicity of methamphetamine: Main effects and mechanisms
Methamphetamine (METH) is a widely abused psychostimulant that can lead to significant health issues. Its use is linked to neurological, psychiatric, and other severe medical complications, including an increased risk of Parkinsonism.
The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis
Drug overdose deaths, primarily from synthetic opioids like fentanyl, are a growing crisis. After a temporary decline in 2018, overdose fatalities dramatically increased in 2019 and 2020, with fentanyl driving the surge across the US.
Cannabis use and cannabis use disorder
Cannabis is the third most used controlled substance globally, with 192 million users in 2018. About 1 in 10 regular users develop cannabis use disorder, risking poor mental health.
Interventions for Cannabis Use Disorder
Psychosocial treatments like motivational therapy, cognitive behavioral therapy, and contingency management reduce cannabis use and its severity.
Non-abstinent treatment outcomes for cannabis use disorder
Cannabis Use Disorder is a major public health problem often focused on abstinence in treatment trials. Some studies now explore reducing cannabis use and withdrawal symptoms as alternative treatment goals.
Brain reward circuitry: The overlapping neurobiology of trauma and substance use disorders
Early trauma research linked dissociation to unresolved memories of negative experiences. Decades of study confirm trauma's broad psychological and biological effects, with PTSD symptoms impacting stress response and brain function.
A Case Report about the Interrelation of Trauma, Emotional and Behavioral Response and Severe Alcohol Use Disorder
This article describes a case study of a male client seeking treatment for anger, violent behavior, and alcohol use. It highlights links between trauma, anger suppression, and substance use, emphasizing culturally informed care.
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
MDMA-assisted therapy significantly reduced PTSD symptoms and functional impairment compared to placebo. It was generally well-tolerated, with more adverse events in the MDMA group.
Adolescent Brain Development and Contextual Influences: a Decade in Review
Recent research has shifted the view of adolescence from problematic to a period of opportunity and creativity. Studies highlight how the adolescent brain is uniquely suited for exploration, learning, and forging social bonds.
Assessing HIV and Overdose Risks for People Who Use Drugs Exposed to Compulsory Drug Abstinence Programs (CDAP): A Systematic Review and Meta-analysis
Globally, drug use leads to many health problems, including HIV and overdose deaths.
Making the "C-ACE" for a Culturally-informed Adverse Childhood Experiences Framework to Understand the Pervasive Mental Health Impact of Racism on Black Youth
Many youth, especially Black youth, experience traumatic events. Racism and racial discrimination are significant stressors. A new model suggests racism is an adverse childhood experience (ACE) that impacts Black youth's mental health.