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Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder
The article finds that changes in brain regions, particularly the BNST network, contribute to relapse in alcohol use disorder. Understanding these changes could help identify individuals at risk and guide new treatments.
Characteristics of Stress Sensitivity in Heroin Use Disorder Patients during Their Opioid Agonist Treatment
Opioid use disorder is a chronic brain disease causing lasting brain changes. This article suggests addiction has a specific psychopathology, distinct from other mental health conditions, that can inform personalized treatment approaches.
Contextual Processing and its Alterations in Patients with Addictive Disorders
Opioid addiction is a major public health issue linked to impaired contextual processing, which impacts decision-making. Researchers are studying how this impairment affects individuals with opioid, alcohol, or both dependencies.
Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain
This article explains that Mu-Opioid Receptors (MORs) are critical for processes like pain and reward. Dysregulation can lead to disorders like addiction and pain. MORs also influence neuroinflammation, which could lead to new treatments.
Dysregulation of the Endogenous Cannabinoid System Following Opioid Exposure
This review summarizes evidence for endocannabinoid system (ECS) dysregulation in opioid use disorder (OUD). It explores how the ECS, a stress regulatory system, could be a new target for OUD treatments.
GABAergic signaling in alcohol use disorder and withdrawal: Pathological involvement and therapeutic potential
Alcohol use disorders affect many people globally and are linked to numerous health issues. While ethanol impacts various brain pathways, a key focus is its effect on the brain's inhibitory GABA pathway.
Investigating Behavioral and Neuronal Changes in Adolescent Mice Following Prenatal Exposure to Electronic Cigarette (E-Cigarette) Vapor Containing Nicotine
E-cigarette exposure during the first trimester of mouse pregnancy led to adolescent offspring having altered anxiety, recognition memory, and increased nicotine preference. These changes suggest a link to psychiatric disorder phenotypes.
Neuropsychological functioning of patients with major depression or bipolar disorder comorbid to substance use disorders: A systematic review
The co-occurrence of substance use disorders and mental health conditions, called dual disorders, is common and linked to worse health outcomes. Major depression and bipolar disorder are the most frequently reported co-occurring conditions.
Default Mode Network Modulation by Psychedelics: A Systematic Review
Psychedelics, known as "mind-manifesting" agents, may alter consciousness by affecting the brain's Default Mode Network (DMN). These effects show promise for treating various neuropsychiatric conditions.
Psychedelics reopen the social reward learning critical period
Research shows that various psychedelics can reopen a "critical period" in the brain, enhancing social reward learning in adulthood. This suggests a common mechanism that may contribute to their therapeutic potential.
Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics
This study explored challenging psychedelic experiences in a representative US adult sample. It examined how psychological traits, medication use, and environment relate to these experiences.
Case analysis of long-term negative psychological responses to psychedelics
This study focuses exclusively on negative psychological responses to psychedelics that last longer than 72 hours. It aims to understand why these long-term negative mental health issues occur, given growing general use.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Researchers discovered that psychedelics like LSD and psilocybin directly bind to a protein called TrkB with high affinity.
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
This study found that certain compounds, including psychedelics, can rapidly promote new brain cell growth and have antidepressant-like effects. This growth appears linked to their ability to activate serotonin receptors inside cells.
Psychedelics: Threshold of a Therapeutic Revolution
This issue updates research on psychedelic drugs, showing remarkable progress in basic and clinical studies since 2018. It details current policies, ethics, and legal considerations for their potential use as mainstream therapies.