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Unravelling Polygenic risk and Environmental Interactions in Adolescent Polysubstance Use: a US Population-Based Observational Study
This study explores how genetic risks and environmental factors interact to influence adolescent polysubstance use. Findings aim to reveal underlying mechanisms and inform prevention strategies for substance use disorders.
Drug Addiction and Incarceration: A Call for Research and Transparency Among Prison-Based Substance Abuse Treatment programs
A significant majority of incarcerated individuals in the U.S. have a history of illicit drug use, and over half have diagnosable addictions. This highlights an urgent need for effective, transparent prison-based treatment programs.
Recruitment of Neuronal Populations in the Paraventricular Thalamus of Alcohol-Seeking Rats With Withdrawal-Related Learning Experience
The study identified neurons activated by environmental cues linked to alcohol in rats, showing different brain activity in dependent versus nondependent animals.
Alternative splicing in addiction
Addiction is a chronic disease marked by compulsive drug or alcohol use despite harmful outcomes, affecting many adults. Drugs of abuse all hijack the brain's reward circuit to increase dopamine, causing reinforcing effects.
Peripheral molecular and brain structural profile implicated stress activation and hyperoxidation in methamphetamine use disorder
This study investigated changes in blood molecules in people with methamphetamine use disorder. It found links between these molecular changes and brain structure alterations, potentially offering insights for treatment.
U.S. substance use harm reduction efforts: A review of the current state of policy, policy barriers, and recommendations
Substance use disorders and overdose deaths are rising, significantly impacting the U.S. Fentanyl drives many overdoses, but other drug-related harms and infectious diseases are also increasing.
Inequities in Opioid Administration by Race and Ethnicity for Hospitalized Patients With and Without Substance Use Disorders
Minority patients with substance use disorders received fewer daily opioid doses for pain management during hospitalization. This disparity remained even after accounting for various clinical and demographic factors.
Helping Opioid Use Disorder and PTSD with Exposure (HOPE): An Open-Label Pilot Study of a Trauma-Focused, Integrated Therapy for OUD/PTSD
Opioid use disorder and posttraumatic stress disorder often occur together, making treatment complex. New integrated psychotherapies are needed for individuals with both conditions to improve treatment outcomes.
Exploring Social Impairment in Those With Opioid Use Disorder: Linking Impulsivity, Childhood Trauma, and the Prefrontal Cortex
Opioid use disorder is a major public health issue, with nearly 80% of drug-related deaths linked to opioids. Impulsivity and childhood adversity are risk factors that can impact treatment and recovery.
Promising Opportunities to Intervene on Adolescent Substance Use
Drug overdose deaths and non-medical prescription drug use have declined among adolescents. Illicit drug, cannabis, alcohol, and nicotine vaping also decreased, though adolescent substance use disorder remains a concern.
Proposed Brief of Amici Curiae Drug Policy Alliance et al. in Support of Appellant’s Motion for Leave to Appeal to the Court of Appeals
This brief argues a father cannot be found negligent for his pregnant partner's drug use. Medical experts oppose punitive actions during pregnancy, citing harm to women, children, and families.
N-acetylcysteine for youth cannabis use disorder: Randomized controlled trial main findings
A study found N-acetylcysteine, an over-the-counter supplement, helped young people aged 14–21 reduce cannabis use when combined with brief counseling. This effect was not observed in adults.
Developmental differences in social information use under uncertainty: A neurocomputational approach
Adolescents are more influenced by peers due to increased uncertainty in new situations. They learn to weigh peer information based on their own knowledge and the peer's perceived expertise.
Risk-Taking Facilitates Implicit Learning in Young Adults
This article examines how risk-taking can lead to learning and positive outcomes, not just negative ones. It highlights the need for more research using objective measures to understand adaptive risk-taking in adults.
"Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder "
A family history of substance use disorder (SUD) and an individual's sex influence their vulnerability to SUD.