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U.S. substance use harm reduction efforts: A review of the current state of policy, policy barriers, and recommendations
Substance use disorders and overdose deaths are rising, significantly impacting the U.S. Fentanyl drives many overdoses, but other drug-related harms and infectious diseases are also increasing.
Inequities in Opioid Administration by Race and Ethnicity for Hospitalized Patients With and Without Substance Use Disorders
Minority patients with substance use disorders received fewer daily opioid doses for pain management during hospitalization. This disparity remained even after accounting for various clinical and demographic factors.
Helping Opioid Use Disorder and PTSD with Exposure (HOPE): An Open-Label Pilot Study of a Trauma-Focused, Integrated Therapy for OUD/PTSD
Opioid use disorder and posttraumatic stress disorder often occur together, making treatment complex. New integrated psychotherapies are needed for individuals with both conditions to improve treatment outcomes.
Exploring Social Impairment in Those With Opioid Use Disorder: Linking Impulsivity, Childhood Trauma, and the Prefrontal Cortex
Opioid use disorder is a major public health issue, with nearly 80% of drug-related deaths linked to opioids. Impulsivity and childhood adversity are risk factors that can impact treatment and recovery.
Promising Opportunities to Intervene on Adolescent Substance Use
Drug overdose deaths and non-medical prescription drug use have declined among adolescents. Illicit drug, cannabis, alcohol, and nicotine vaping also decreased, though adolescent substance use disorder remains a concern.
N-acetylcysteine for youth cannabis use disorder: Randomized controlled trial main findings
A study found N-acetylcysteine, an over-the-counter supplement, helped young people aged 14–21 reduce cannabis use when combined with brief counseling. This effect was not observed in adults.
Developmental differences in social information use under uncertainty: A neurocomputational approach
Adolescents are more influenced by peers due to increased uncertainty in new situations. They learn to weigh peer information based on their own knowledge and the peer's perceived expertise.
"Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder "
A family history of substance use disorder (SUD) and an individual's sex influence their vulnerability to SUD.
From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS)
The study found that psilocybin reduced confidence in negative self-beliefs, both immediately and weeks later. This suggests psychedelics could help revise unhelpful thought patterns and improve well-being.
Neurobiological intersections of stress and substance use disorders
Substance Use Disorders (SUDs) are brain diseases characterized by compulsive drug seeking despite negative consequences. Stress significantly contributes to SUD development and relapse by impacting brain reward and stress systems.
Efficacy and Clinical Application of Physical Activity in Substance Use Disorder Rehabilitation: A Review on Mechanism and Benefits
Physical activity (PA) offers a comprehensive approach to treating substance use disorders (SUDs) by enhancing brain function, reducing cravings, and improving mood. Regular PA supports long-term recovery and overall well-being.
The role of personality functioning and childhood trauma in patients in opioid substitution treatment
The study found that individuals with opioid use disorders in a substitution program have significant impairments in personality functioning, which are linked to childhood trauma and injecting drug use.
Novel Insights into Addiction Management: A Meta-Analysis on Intervention for Relapse Prevention
Addiction is a chronic brain disorder, and relapse rates for substance use remain high after treatment. This analysis explores recent developments in preventing relapse from alcohol and drug addiction.
Exploration of Effective Substance Use Relapse Prevention Programmes for the Youth: An Integrative Literature Review
Many young people with substance use disorders relapse after treatment. Effective relapse prevention programs, considering social and cultural factors, are crucial for supporting long-term recovery in youth.
MDMA and MDMA-Assisted Therapy
Studies show MDMA-Assisted Therapy effectively treats PTSD, but the FDA requires further research before approval. It's crucial to distinguish between clinical MDMA therapy and recreational MDMA use.