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Case analysis of long-term negative psychological responses to psychedelics
This study focuses exclusively on negative psychological responses to psychedelics that last longer than 72 hours. It aims to understand why these long-term negative mental health issues occur, given growing general use.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Researchers discovered that psychedelics like LSD and psilocybin directly bind to a protein called TrkB with high affinity.
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
This study found that certain compounds, including psychedelics, can rapidly promote new brain cell growth and have antidepressant-like effects. This growth appears linked to their ability to activate serotonin receptors inside cells.
Psychedelics: Threshold of a Therapeutic Revolution
This issue updates research on psychedelic drugs, showing remarkable progress in basic and clinical studies since 2018. It details current policies, ethics, and legal considerations for their potential use as mainstream therapies.
Cocaine or Methamphetamine Use During Young Adulthood Following Stimulant Use for Attention-Deficit/Hyperactivity Disorder During Adolescence
Adolescents prescribed stimulants for ADHD did not show an increased risk of later illicit stimulant use. However, adolescents misusing prescription stimulants had a higher risk of later using cocaine or methamphetamine.
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
MDMA-assisted therapy significantly reduced PTSD symptoms and functional impairment in a diverse population with moderate to severe PTSD. The treatment was well-tolerated.
Neurocognitive Recovery in Abstinent Patients with Alcohol Use Disorder: A Scoping Review for Associated Factors
Chronic alcohol use disorder often leads to cognitive impairments that hinder treatment success. While abstinence can help, recovery varies, and more longitudinal research is needed to understand influencing factors beyond just abstinence.
Pathways to the persistence of drug use despite its adverse consequences
This article identifies three pathways—cognitive, motivational, and behavioral—that explain why individuals continue drug use despite negative consequences. These pathways can operate differently within an individual over time.
The genetically informed neurobiology of addiction (GINA) model
Addiction is now understood as a neurobiological state influenced by genetics and environment. A new model, GINA, explains how genetic risk and substance-induced brain changes contribute to addiction's development.
Alcohol use disorder-associated structural and functional characteristics of the insula
Chronic alcohol use is linked to altered brain function and structure, particularly in areas related to executive function and emotion. Studies show changes in the insula, a key brain region, are associated with alcohol use disorder.
Time for a paradigm shift: The adolescent brain in addiction treatment
Adolescent brain development uniquely impacts problem drinking and treatment effectiveness. Research highlights distinct neural responses in teens during therapy, suggesting new approaches are needed.
Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use
Adolescent substance use, though declining, remains prevalent and can negatively impact brain development, increasing future risk. Identifying genetic risk factors may help target preventative strategies.
Crime-Specific Recidivism in Criminal Justice Clients with Substance Use - A Cohort Study
Previously sentenced individuals often reoffend, with high reconviction rates globally. Substance use disorders are strongly linked to increased offending, and mental health issues are common among those with SUDs.
Neurobiological mechanisms and related clinical treatment of addiction: A review
Substance use disorder (SUD) is a chronic, relapsing brain disease characterized by compulsive drug seeking, loss of control, and negative emotional states.
Expanding the continuum of substance use disorder treatment: Nonabstinence approaches
Many adults with substance use disorders (SUDs) do not receive treatment, often because current abstinence-focused methods do not align with their goals.