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The Developmental Origins of Opioid Use Disorder and Its Comorbidities
Early life adversity can disrupt the brain's reward system, increasing the risk for opioid use disorder and co-occurring mental health issues like depression. This impact can differ between biological sexes.
Impulsive trait mediates the relationship between white matter integrity of prefrontal-striatal circuits and the severity of dependence in alcoholism
Alcohol dependence is a chronic relapsing disease that impairs control over drinking despite negative consequences. Impulsivity increases relapse risk due to weakened brain pathways controlling inhibition.
Enduring disruption of reward and stress circuit activities by early-life adversity in male rats
Early-life adversity in male rats leads to a reduced response to opioid rewards, suggesting a form of anhedonia for these drugs. This blunted behavior may involve altered brain activation in reward and stress circuits.
Addiction Treatment and Telehealth: Review of Efficacy and Provider Insights During the COVID-19 Pandemic
Telehealth for addiction treatment shows similar outcomes to in-person care for retention and satisfaction. Providers believe it improves access and works best for individual counseling.
Consideration of sex and gender differences in addiction medication response
Research shows sex and gender are often overlooked in addiction medication development. This can lead to different treatment responses between men and women, impacting care for substance use disorders.
An unknown invisible intrusion. Impact of an adult family member’s problematic substance use on family life: a meta-ethnography
Problematic substance use significantly harms both individuals and their families. While the user's struggles are acknowledged, the profound, far-reaching impact on close family members often goes unaddressed.
School Health Predictors of the School-to-Prison Pipeline: Substance Use and Developmental Risk and Resilience Factors
This study found that student substance use and other risk factors in schools predict school discipline and police contact. These outcomes are key components of the "school-to-prison pipeline."
Addressing adolescent substance use with a public health prevention framework: The case for harm reduction
Harm reduction principles should be integrated with traditional prevention for adolescents with problematic substance use. This approach can help minimize negative health and social impacts.
Association between contact with mental health and substance use services and reincarceration after release from prison
A study found that people receiving mental health or substance use services after prison release had a lower risk of re-incarceration. However, consistent engagement with these services improved outcomes more.
PriSUD-Nordic—Diagnosing and Treating Substance Use Disorders in the Prison Population: Protocol for a Mixed Methods Study
This project examines substance use disorders in Nordic prisons across three periods: before, during, and after imprisonment. It combines extensive registry data with qualitative research to understand this vulnerable population.
Perspectives of Adults with Disabilities and Opioid Misuse: Qualitative Findings Illuminating Experiences with Stigma and Substance Use Treatment
Adults with disabilities are more likely to misuse prescription opioids and experience opioid use disorders. They face unique barriers to treatment, including stigma and inaccessible care, compounded by their other identities.
Amicus Curiae Brief in Support of Respondent on Review by Amicus Drug Policy Alliance
This brief argues that using only drug weight and packaging to prove intent to deliver unfairly treats drug possession as attempted delivery. It states these factors are unreliable indicators of an intent to sell.
Stimulant use disorder diagnosis and opioid agonist treatment dispensation following release from prison: A cohort study
People released from prison are at high risk for overdose. This study found that a history of stimulant use disorder reduced the likelihood of receiving critical opioid addiction treatment within two days of release in British Columbia.
Neural substrates of substance use disorders
Subcortical disease and lack of prefrontal control are common findings in neuroimaging studies of substance use. It is still unclear if these are pre-existing traits or consequences of substance use.
Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies
This review focuses on longitudinal neuroimaging studies to understand how the brain changes during abstinence from substance use. It aims to identify mechanisms associated with sustained abstinence or relapse.