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Neural circuits controlling choice behavior in opioid addiction
Opioid use disorder is a growing epidemic characterized by choosing drugs over natural rewards. Research explores the brain's opioid system and neural circuits to develop new treatments that shift this choice behavior.
Chronic alcohol exposure differentially alters calcium activity of striatal cell populations during actions
Chronic alcohol exposure leads to lasting increases in direct pathway activity but reduces indirect pathway and PV interneuron activity in the brain's decision-making region. This imbalance may contribute to impaired behavioral control.
Anticipatory reward dysfunction in alcohol dependence: An electroencephalography monetary incentive delay task study
This study investigated reward processing in alcohol-dependent individuals using EEG.
Prescription psychostimulants for cocaine use disorder: A review from molecular basis to clinical approach
Cocaine use disorder lacks FDA-approved treatment options. Prescription psychostimulants, which share pharmacological effects with cocaine, show promise in promoting abstinence and reducing drug use.
Project Harmony: A Meta-Analysis With Individual Patient Data on Behavioral and Pharmacologic Trials for Comorbid Posttraumatic Stress and Alcohol or Other Drug Use Disorders
New research analyzed 36 trials to find the most effective treatments for co-occurring PTSD and substance use disorders. It found various behavioral and pharmacotherapy options, but noted a need for more comparative studies.
Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect
Women often experience a faster progression from initial substance use to developing a substance use disorder, known as the "telescoping effect." This pattern is seen with various substances, though some recent studies show inconsistencies.
Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders
Adolescents with PTSD have brain changes that may link to developing substance use disorders (SUDs). This review examines neuroimaging studies on this connection and discusses prevention and accurate diagnosis.
Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders
This article reviews brain-based factors tied to recovery from substance use and behavioral addictions. It explores how various treatments, including medication and therapy, relate to brain mechanisms and improved outcomes.
Three decades of research in substance use disorder treatment for syringe services program participants: A scoping review of the literature
Syringe Services Programs reduce disease transmission and connect people who use drugs to medical care. These programs are potential sites to expand substance use disorder treatment, including medication for opioid use disorder.
Estimated Costs and Outcomes Associated with Use and Nonuse of Medications for Opioid Use Disorder During Incarceration and at Release in Massachusetts
Treating incarcerated individuals with opioid use disorder (OUD) through screening and medication can save lives and reduce healthcare costs. This approach also improves treatment retention after release.
The role of substance use treatment in reducing stigma after release from incarceration: A qualitative analysis
Substance use treatment may reduce the stigma experienced by individuals recently released from incarceration. Positive interactions with treatment staff and peers could lessen feelings of shame and judgment.
Racial inequities and addiction research
NIDA prioritizes research on health disparities and diversity in the scientific workforce, studying substance use trends and underlying causes. Acknowledging race and ethnicity data limitations is key to developing effective interventions.
The role of substance use in the lives of incarcerated older adults: A qualitative study
The number of incarcerated older adults (IOAs) and their drug abuse has risen. Research on IOAs and drug abuse is limited, despite this group's unique drug use patterns and a surprising lack of treatment programs.
“Safer Drug Supply” Measures in Canada to Reduce the Drug Overdose Fatality Toll: Clarifying Concepts, Practices and Evidence Within a Public Health Intervention Framework
Canada and the US face a drug toxicity crisis, primarily from synthetic opioids. Current interventions have not stopped rising deaths. "Safer supply" initiatives aim to reduce overdose risk by providing pharmaceutical-grade drugs.
Treating addiction with deep brain stimulation: Ethical and legal considerations
Early brain surgeries for mental health problems led to serious side effects. Newer brain stimulation methods are being explored for addiction, showing some promise but needing more research.