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Time for a paradigm shift: The adolescent brain in addiction treatment
Adolescent brain development uniquely impacts problem drinking and treatment effectiveness. Research highlights distinct neural responses in teens during therapy, suggesting new approaches are needed.
Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use
Adolescent substance use, though declining, remains prevalent and can negatively impact brain development, increasing future risk. Identifying genetic risk factors may help target preventative strategies.
Biological aging processes underlying cognitive decline and neurodegenerative disease
As people age, many core cognitive abilities begin to decline, and brain changes include reduced gray matter. This decline is not a sudden drop but a gradual decrease in abilities across the lifespan.
Crime-Specific Recidivism in Criminal Justice Clients with Substance Use - A Cohort Study
Previously sentenced individuals often reoffend, with high reconviction rates globally. Substance use disorders are strongly linked to increased offending, and mental health issues are common among those with SUDs.
Neurobiological mechanisms and related clinical treatment of addiction: A review
Substance use disorder (SUD) is a chronic, relapsing brain disease characterized by compulsive drug seeking, loss of control, and negative emotional states.
Expanding the continuum of substance use disorder treatment: Nonabstinence approaches
Many adults with substance use disorders (SUDs) do not receive treatment, often because current abstinence-focused methods do not align with their goals.
The treatment of substance use disorders: Recent developments and new perspectives
The article reviews novel therapies for substance use disorders, focusing on cognitive-behavioral, neurobiological, and pharmacological approaches.
Identification of the risk genes associated with vulnerability to addiction: Major findings from transgenic animals
Researchers are identifying specific genes that may increase the risk of substance use disorders. Studies suggest that reduced expression of certain dopamine receptors (D2 and D3) may be risk factors for stimulant, opioid, and alcohol use.
Alcohol use disorder: Neurobiology and therapeutics
Alcohol use disorder is a serious health condition affecting millions globally, characterized by compulsive alcohol use despite negative consequences. Chronic alcohol consumption profoundly affects the brain and other body systems.
Neuroscientific basis of treatment for substance use disorders
Substance use disorder (SUD) is a chronic brain disease impacting the reward system. Current treatments aim to block substance effects, mimic them to ease withdrawal, or intervene in the addiction process itself.
Review of medication-assistend treatment for opioid use disorder
Medication-assisted treatment (MAT) is an effective approach to treating opioid use disorder. Primary care settings are equally effective as specialty care for MAT, offering better access and addressing co-occurring health issues.
Outcomes from the medication assisted treatment pilot program for adults with opioid use disorders in rural Colorado
A rural pilot program for opioid use disorder treatment improved participants' physical and mental health. Patients also saw improvements in social functioning, employment, and reduced legal system involvement.
Relapse on the road to recovery: Learning the lessons of failure on the way to successful behavior change
The vignettes illustrate how individuals struggle to maintain new behaviors and often relapse, especially with addictive behaviors. Relapse is a common challenge in various behavior changes, not just addiction.
Predicting relapse in substance use: Prospective modeling based on intensive longitudinal data on mental health, cognition, and craving
This study found that craving, self-control, and mental distress are linked to substance use relapse. Understanding these dynamic factors in real-time could improve personalized interventions for patients.
Brain tract structure predicts relapse to stimulant drug use
This article explores brain connections to the nucleus accumbens, a key region in addiction. It investigates whether the structure of these connections can predict relapse in individuals with stimulant use disorder.