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The treatment of substance use disorders: Recent developments and new perspectives
The article reviews novel therapies for substance use disorders, focusing on cognitive-behavioral, neurobiological, and pharmacological approaches.
Identification of the risk genes associated with vulnerability to addiction: Major findings from transgenic animals
Researchers are identifying specific genes that may increase the risk of substance use disorders. Studies suggest that reduced expression of certain dopamine receptors (D2 and D3) may be risk factors for stimulant, opioid, and alcohol use.
Alcohol use disorder: Neurobiology and therapeutics
Alcohol use disorder is a serious health condition affecting millions globally, characterized by compulsive alcohol use despite negative consequences. Chronic alcohol consumption profoundly affects the brain and other body systems.
Neuroscientific basis of treatment for substance use disorders
Substance use disorder (SUD) is a chronic brain disease impacting the reward system. Current treatments aim to block substance effects, mimic them to ease withdrawal, or intervene in the addiction process itself.
Review of medication-assistend treatment for opioid use disorder
Medication-assisted treatment (MAT) is an effective approach to treating opioid use disorder. Primary care settings are equally effective as specialty care for MAT, offering better access and addressing co-occurring health issues.
Outcomes from the medication assisted treatment pilot program for adults with opioid use disorders in rural Colorado
A rural pilot program for opioid use disorder treatment improved participants' physical and mental health. Patients also saw improvements in social functioning, employment, and reduced legal system involvement.
Relapse on the road to recovery: Learning the lessons of failure on the way to successful behavior change
The vignettes illustrate how individuals struggle to maintain new behaviors and often relapse, especially with addictive behaviors. Relapse is a common challenge in various behavior changes, not just addiction.
Predicting relapse in substance use: Prospective modeling based on intensive longitudinal data on mental health, cognition, and craving
This study found that craving, self-control, and mental distress are linked to substance use relapse. Understanding these dynamic factors in real-time could improve personalized interventions for patients.
Brain tract structure predicts relapse to stimulant drug use
This article explores brain connections to the nucleus accumbens, a key region in addiction. It investigates whether the structure of these connections can predict relapse in individuals with stimulant use disorder.
Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction
Early life adversity is strongly linked to a higher risk of developing substance use disorder. It impacts brain development, making individuals, especially women, more vulnerable to addiction later in life.
The neurobiology of drug addiction: Cross-species insights into the dysfunction and recovery of the prefrontal cortex
Drug addiction is a chronic disease that causes widespread brain changes. This article reviews how drug abuse affects the prefrontal cortex, which is involved in emotion and decision-making.
Association of drug cues and craving with drug use and relapse: A systematic review and meta-analysis
A review of 237 studies found a significant link between drug cues, craving, and future drug use or relapse. These findings suggest that drug cues and craving are key factors in understanding drug use.
Prevalence of Mental Health Needs, Substance Use, and Co-occurring Disorders Among People Admitted to Prison
The number of people admitted to prison with both mental health needs and substance use disorders rose between 2009 and 2017. Methamphetamine and heroin use disorders increased, while cocaine use disorder decreased.
Gender differences among persons entering medication treatment for opioid use disorder in the community
Women beginning medication treatment for opioid use disorder (MOUD) were younger, more often White non-Hispanic and LGBTQ+, and had less incarceration than men.
Emotional Dysregulation in Children and Adolescents
Emotional dysregulation, or difficulty managing emotions, is a major health risk for children and adolescents. It is linked to various psychiatric disorders, self-harm, and suicidality, and can result from adverse childhood experiences.