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Case analysis of long-term negative psychological responses to psychedelics
This study focuses exclusively on negative psychological responses to psychedelics that last longer than 72 hours. It aims to understand why these long-term negative mental health issues occur, given growing general use.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Researchers discovered that psychedelics like LSD and psilocybin directly bind to a protein called TrkB with high affinity.
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
This study found that certain compounds, including psychedelics, can rapidly promote new brain cell growth and have antidepressant-like effects. This growth appears linked to their ability to activate serotonin receptors inside cells.
Psychedelics: Threshold of a Therapeutic Revolution
This issue updates research on psychedelic drugs, showing remarkable progress in basic and clinical studies since 2018. It details current policies, ethics, and legal considerations for their potential use as mainstream therapies.
Cocaine or Methamphetamine Use During Young Adulthood Following Stimulant Use for Attention-Deficit/Hyperactivity Disorder During Adolescence
Adolescents prescribed stimulants for ADHD did not show an increased risk of later illicit stimulant use. However, adolescents misusing prescription stimulants had a higher risk of later using cocaine or methamphetamine.
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
MDMA-assisted therapy significantly reduced PTSD symptoms and functional impairment in a diverse population with moderate to severe PTSD. The treatment was well-tolerated.
Neurocognitive Recovery in Abstinent Patients with Alcohol Use Disorder: A Scoping Review for Associated Factors
Chronic alcohol use disorder often leads to cognitive impairments that hinder treatment success. While abstinence can help, recovery varies, and more longitudinal research is needed to understand influencing factors beyond just abstinence.
Pathways to the persistence of drug use despite its adverse consequences
This article identifies three pathways—cognitive, motivational, and behavioral—that explain why individuals continue drug use despite negative consequences. These pathways can operate differently within an individual over time.
Daring and Distress: Insights on Adolescent Risk Taking and Difficulties in Emotion Regulation from a Network Analysis Perspective
This article explores how adolescent risk-taking differs from self-harm. It highlights that risk-taking often involves social contexts and seeking excitement, while self-harm is driven by distress and coping difficulties.
Homicide and Criminal Maturity of Juvenile Offenders: A Critical Review
The Supreme Court’s Miller v. Alabama decision struck down mandatory life without parole for juvenile murderers. The Court cited juveniles' diminished culpability and greater potential for reform.
How Important Is Developmental Maturity in Assessing Whether Adolescents Will Share True or False Accounts of a First Offense in Legal Interactions?
Adolescents often feel pressure during legal interactions, which can affect their truthfulness. They may conceal information or give false confessions due to fear or a desire to avoid immediate discomfort.
Neurobiological Development in Adolescence and Early Adulthood: Implications for Positive Youth Adjustment
Adolescent brains undergo dramatic, positive development into their 20s and 30s. Media often mischaracterizes this period, linking negative stereotypes to increased risk-taking in youth.
Redefining Youth: The Case for Applying the Principles of Miller v. Alabama to Criminal Cases Involving Adults in Late Adolescence
This article argues that late adolescents, ages 18-21, should receive similar sentencing considerations as juveniles due to their brain development and capacity for rehabilitation.
Risk-Taking Behavior of Adolescents and Young Adults Born Preterm
Young adults born preterm had lower rates of teenage pregnancies, sexually transmitted infections, payment defaults, substance abuse, and criminal offenses compared to those born at full term.
The Teenage Brain: Sensitivity to Social Evaluation
Adolescence is marked by increased social sensitivity, where social evaluation and peer relationships become intensely important.