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The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists

Substance use disorder (SUD) involves a powerful habit network in the brain. Treatments can help patients change these patterns by reducing cravings, blocking rewarding effects of substances, and easing withdrawal.

Substance use disorderSUD treatmentneuroplasticityketaminepsilocybinTMSstressaddiction
(2024)

The Incentive-Sensitization Theory of Addiction 30 years on

A theory of addiction suggests that drug use can increase "wanting" for drugs over time, even if the "liking" or pleasure from them decreases. This "wanting" is driven by changes in specific brain systems.

addictionsensitizationdopaminemotivationwantingcravingliking
(2024)

From relapse prevention to recovery protection: A positive perspective on recovery from substance use disorder

Harmful drug and alcohol use leads to millions of deaths and widespread suffering annually. Supporting individuals in maintaining abstinence is crucial to reducing this public health burden.

recovery protectionreturn to use preventionsubstance use disorderrecovery modeladdiction recoveryG-CHIME
(2024)

A probabilistic model of relapse in drug addiction

Drug overdose deaths have sharply risen, with addiction now seen as a chronic brain disease. Relapse is common, often triggered by stress, cues, and the memory of a first drug high.

Drug addictionMood dynamicsPeak-end rulePositive/negative activationReturn to use
(2024)

In re California Palms Addiction Recovery Campus

The court addressed a substance abuse center's closure, bankruptcy, and disputes over licensing, patient care, and financial mismanagement.

Substance use treatmentbankruptcylicensing disputespatient care standards financial mismanagementcourt casetreatment center closurehealthcarelegal dispute
(2024)

In Re Social Media Adolescent Addiction Litigation

The court ruled that social media companies must face claims alleging addictive designs harmed adolescent mental health, citing sufficient evidence of a defect and causation.

social mediaaddictionmental healthadolescentsproduct liabilitynegligence2024 lawsuitsocial media platformsharmful featuresdesign
(2024)

People v. Smallwood

The court upheld a life sentence for attempted murder. It rejected claims that the sentence was unconstitutional given the defendant's mental illness, substance use, and early trauma.

Eighth Amendmentproportionalityattempted murder life sentencemental illnesssubstance useearly trauma
(2024)

State v. Schober

The West Virginia high court upheld the denial of a probationer's request to use medical cannabis. The court ruled the state's Cannabis Act does not override probation terms or federal law.

medical cannabisprobationmarijuanamarijuana ban
(2024)

United States v. Burchfield

The court ruled a defendant claiming delusions of secret societies was competent to stand trial. This decision followed expert evaluation and testimony.

malingeringsubstance use disordersdelusionssecret societiesspaceships legal competency expert evaluationtestimony
(2024)

United States v. Antonio Taylor

The Sixth Circuit affirmed a conviction, finding a defendant competent despite mental health issues and substance use. The court noted evidence of malingering and a rational understanding of proceedings.

convictioncompetencypersonality disorders alcohol use disordercocaine use disordermalingeringrational understandingclear error
(2024)

DiFraia v. Ransom

DiFraia sued prison officials after being denied opioid-use-disorder medication. The court dismissed individual claims without ruling on substance-use rights.

ADAEighth Amendmentopioid-use-disorder medicationprison officialssubstance-use rightsindividual-capacity claims
(2024)

Cannabis use disorder: From neurobiology to treatment

Cannabis use disorder is a chronic condition affecting millions, especially young adults. The risk of developing CUD increases with the frequency of cannabis use and co-occurs with other mental health conditions.

Cannabis use disorderCUDTHCpsychological interventionspharmacological interventionsCB1 receptorendocannabinoid systemprevalencetreatmentheritability
(2024)

State v. Matrongolo

The court found that drug use could be introduced to question a witness's credibility. This raised due process concerns about addiction's relevance in criminal trials.

drug usewitness credibilityimpeachmentdue processevidentiary questionsaddictionlegal relevancecriminal trials
(2024)

Stress and substance use disorders: Risk, relapse, and treatment outcomes

Stress is a common reason for drug misuse, which can be seen as a coping mechanism. This review introduces an "adaptive stress response" framework and outlines how disruptions in this response contribute to addiction.

addictionsubstance use disorders (SUDs)stress responsecoping mechanismsneurobiological modelsrelapsetreatment failurestress pathophysiologyaddiction risk
(2024)

Harm reduction for Opioid Use Disorder: Strategies and outcome metrics

The opioid crisis has led to over one million overdose deaths. Harm reduction strategies, such as syringe exchange programs, are crucial to mitigate negative consequences and save lives, especially given low treatment initiation rates.

harm reductionoverdose preventionnaloxonesyringe exchangesupervised consumptionsafer supplyfentanyldrug decriminalizationOpioid use disorderoutcome metrics
(2024)
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