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The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates

Substance use disorders and other mental health conditions share common genetic vulnerabilities. Understanding these genetic links could lead to better prevention and treatment.

Genetics researchBehavioural geneticsAddictionSubstance use disordergenetic liabilitypsychopathologyrisk-takingexecutive functionneuroticismgenome-wide association study (GWAS)genetic correlationpolygenic liability
(2022)

Neuropsychiatric Model of Addiction Simplified

Research shows addiction is a chronic, relapsing brain disorder influenced by both genetics and environment. Early life stress increases substance use risk, but interventions can mitigate these effects.

AddictionAddiction cycleNeurobiologyReinforcementdopaminewithdrawalrelapseneuroplasticitycravingtreatment
(2022)

Persistent and Distressing Psychotic-Like Experiences Using Adolescent Brain Cognitive Development℠ Study Data

Children who experience persistent and distressing psychotic-like experiences show greater impairments across multiple areas.

Childhood psychotic-like experiencesPLEsdistressdevelopmental delaysbrain structure
(2022)

Prosocial Development in Adolescence

Adolescents demonstrated strong adherence to COVID-19 restrictions despite experiencing the most negative effects. Prosocial behavior, which benefits others, is crucial for collective well-being during health crises.

Prosocial behavioradolescencesocial adjustmentsocial brain developmentenvironmental influencesCOVID-19 pandemicCOVID-19
(2022)

Raging Hormones: Why Age-Based Etiological Conceptualizations of the Development of Antisocial Behavior Are Insufficient

Current legal use of neuroscience in courtrooms often overlooks how puberty and hormones influence adolescent antisocial behavior. Greater focus on these factors is needed for accurate legal applications of science.

Developmental neurosciencemodern legal systemantisocial behaviorpubertyhormonesbrain plasticity
(2022)

Risks and Rewards in Adolescent Decision-Making

Adolescence is a time of increased reward-sensitivity and risk-taking. While risk preference can be stable, it changes with age and social context. Self-reports are reliable for measuring risk preference.

Risk takingAdolescentsIndividual differencesSocial influenceInsulaRisk-return
(2022)

Development of Corticostriatal Connectivity Constrains Goal-directed Behavior During Adolescence

This research explores how individuals adjust cognitive effort based on potential rewards. It finds that older participants improve performance in high-stakes situations, a capacity linked to developing brain connections.

Brain development Children Adults GoalsDecision making
(2022)

Stress and Adolescence: Vulnerability and Opportunity During a Sensitive Window of Development

Adolescence is a crucial time when stress can significantly impact brain development and mental health. While it poses heightened risks, this period also offers unique opportunities for resilience and positive recalibration.

adolescencestresssupport
(2022)

The Neurobiology of Antisocial Behavior in Adolescence; Current Knowledge and Relevance for Youth Forensic Clinical Practice

This article reviews the neurobiological factors linked to antisocial behavior in adolescents, including genetic influences and brain differences.

Antisocial behaviorbiopsychosocial approachrisk assessmentneuropsychologyneuroimagingpsychopathic traitsneurobiologyneurodevelopmental problemsadolescence
(2022)

The Power of Friendship: the Developmental Significance of Friendships from a Neuroscience Perspective

Friendships contribute to well-being, protect against negative effects, and predict healthy psychosocial functioning. Research indicates that interacting with friends activates brain regions associated with reward.

brain developmentfriendshipsrewardsadolescents
(2022)

Time for a Paradigm Shift: The Adolescent Brain in Addiction Treatment

Adolescent problem drinking is common, yet treatments often have limited effectiveness due to unique brain development. Brain regions for self-awareness may respond differently during therapy for adolescents.

adolescentaddictiontreatmentMRItherapist language
(2022)

Toward Children’s Cognitive Development From the Perspective of Neurolaw: Implications of Roper v Simmons

New scientific understanding of child brain development has changed how legal systems view juvenile delinquency. This led to the U.S. Supreme Court ending the juvenile death penalty in the Roper v. Simmons case.

cognitive developmentjuvenile delinquencyneurolawRoper v SimmonsU.S. Supreme Court
(2022)

Understanding the Dynamics of the Developing Adolescent Brain Through Team Science

Adolescence is a critical period of physical, psychological, and social changes, making it a sensitive time for mental health. Understanding these intertwined changes requires comprehensive measurements and collaborative research.

Review articleAdolescentsBrain developmentsocial developmentmental wellbeingteen science
(2022)

The effects of naltrexone on retention in treatment and being opioid-free in opioid-dependent people: A systematic review and meta-analysis

A review found naltrexone treatment for opioid dependence increased patients staying in treatment and remaining opioid-free. It highlights the drug's effectiveness for recovery.

opioidnaltrexoneretention in treatmentopioid freesystematic reviewmeta-analysis
(2022)

FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors

Addictions to substances and behaviors share psychological, biological, and genetic overlaps. These conditions often co-occur and involve similar brain systems and genetic predispositions.

addictive behaviorsgenetic association analysissubstance usesubstance-related disordersFOXN3GDNF
(2022)
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