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Network Analysis of DSM Symptoms of Substance Use Disorders and Frequently Co-Occurring Mental Disorders in Patients with Substance Use Disorder Who Seek Treatment

Substance use disorders often co-occur with other mental health conditions. Understanding the links between symptoms across these disorders can improve diagnosis and treatment outcomes.

network analysissubstance use disordersADHDcomorbiditypersonality disordersgender differencesborderline personalityconduct disorder
(2022)

Opioid Overdose Deaths Among Formerly Incarcerated Persons and the General Population: North Carolina, 2000‒2018

Formerly incarcerated persons in North Carolina face a significantly higher risk of opioid overdose death compared to the general population, especially from synthetic narcotics like fentanyl. This risk is highest immediately after release.

Formerly incarcerated persons opioid overdose deathNorth Carolinapostreleasefentanylstandardized mortality ratiosubstance use disordersre-entryopioid epidemicincarceration
(2022)

The prevalence of comorbid serious mental illnesses and substance use disorders in prison populations: a systematic review and meta-analysis

Many people in prison have co-occurring serious mental illnesses and substance use disorders. This significantly increases their risk of reincarceration and suicide attempts after release.

Prison populationdual disorderscomorbid mental illnesssubstance use disorderspsychosismajor depressionincarcerationtreatment outcomesintegrated servicesmental health in prison
(2022)

Defining Recovery From Alcohol Use Disorder: Development of an NIAAA Research Definition

The article introduces a new research definition of recovery from Alcohol Use Disorder (AUD) developed by NIAAA. This definition aims to standardize research, track the course of AUD, and improve understanding of treatment responses.

Alcohol use disorderrecoveryDSM-5 AUDNIAAA definitionheavy drinkingremissionabstinencebiopsychosocial functioningwell-beingtreatment
(2022)

Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder

Alcohol use disorder is often undertreated. New and existing medications show promise for future treatment, including personalized approaches for diverse patient needs.

Alcohol use disordertreatmentpharmacotherapiesnaltrexoneacamprosatedisulfiramharm reductionabstinencerepurposed medicationsnovel agents
(2022)

Gene-based polygenic risk scores analysis of Alcohol Use Disorder in African Americans

This study proposes a new gene-based method to improve genetic risk prediction for alcohol use disorder in diverse populations. It focuses on shared disease-causing genes between different ancestries.

Alcohol use disorderpolygenic risk scoregenome-wide association studyAUD risk predictiondrug targets
(2022)

Alcohol Use Disorder in the COVID-19 era: Position paper of the Italian Society on Alcohol (SIA)

The Italian Society of Alcohology (ISA) developed guidelines for managing alcohol use disorder (AUD) in COVID-19 patients. This addresses increased AUD during lockdowns and the unique challenges posed by co-occurring COVID-19 infection.

COVID-19alcohol use disordertelehealthtelemedicinedrug interactionsalcohol consumptionliver cirrhosisrelapse preventionCAATsvaccination
(2022)

Understanding Stimulant Use and Use Disorders in a New Era

Drug overdose deaths are rising due to illicit opioids, stimulants like methamphetamine and cocaine, and their co-use. This "fourth wave" of mortality is driven by increased supply and potency of these substances.

Behavioral treatmentsCocaineEpidemiologyFentanylMedication treatmentsMethamphetamineNeurobiologyPharmacology
(2022)

The Developmental Origins of Opioid Use Disorder and Its Comorbidities

Early life adversity can disrupt the brain's reward system, increasing the risk for opioid use disorder and co-occurring mental health issues like depression. This impact can differ between biological sexes.

addictionanhedoniacircuitearly life stressextinctionopioidsrewardsex
(2022)

Impulsive trait mediates the relationship between white matter integrity of prefrontal-striatal circuits and the severity of dependence in alcoholism

Alcohol dependence is a chronic relapsing disease that impairs control over drinking despite negative consequences. Impulsivity increases relapse risk due to weakened brain pathways controlling inhibition.

alcohol dependencediffusion tensor imagingimpulsivityprobabilistic tractographysystematic striatal circuits
(2022)

Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

Early-life adversity in male rats leads to a reduced response to opioid rewards, suggesting a form of anhedonia for these drugs. This blunted behavior may involve altered brain activation in reward and stress circuits.

Early-life adversityopioid addictionanhedoniareward circuitstress circuitnucleus accumbens amygdalaprefrontal cortexopioid self-administrationc-Fos expression
(2022)

Addiction Treatment and Telehealth: Review of Efficacy and Provider Insights During the COVID-19 Pandemic

Telehealth for addiction treatment shows similar outcomes to in-person care for retention and satisfaction. Providers believe it improves access and works best for individual counseling.

Telehealth addiction treatmenttelehealth effectivenessin-person treatmentaddiction treatment accessmedication-assisted treatmentopioid use disordersubstance use disordertelehealth limitationstelehealth benefitshybrid treatment approach
(2022)

Consideration of sex and gender differences in addiction medication response

Research shows sex and gender are often overlooked in addiction medication development. This can lead to different treatment responses between men and women, impacting care for substance use disorders.

Substance use disordersex differencesgender differencesaddiction medicationclinical trialsnicotinealcoholcocainecannabisopioids
(2022)

An unknown invisible intrusion. Impact of an adult family member’s problematic substance use on family life: a meta-ethnography

Problematic substance use significantly harms both individuals and their families. While the user's struggles are acknowledged, the profound, far-reaching impact on close family members often goes unaddressed.

Problematic substance usefamily impactfamily lifemeta-ethnography
(2022)

School Health Predictors of the School-to-Prison Pipeline: Substance Use and Developmental Risk and Resilience Factors

This study found that student substance use and other risk factors in schools predict school discipline and police contact. These outcomes are key components of the "school-to-prison pipeline."

School disciplineSubstance useSchool-to-prison pipeline
(2022)