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Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum A Randomized Clinical Trial
A clinical trial found extended-release buprenorphine to be as effective and safe as sublingual buprenorphine for treating opioid use disorder in pregnant people. This extended-release option helps improve adherence and reduce misuse risks.
Long-term relapse: markers, mechanisms, and implications for disease management in alcohol use disorder
Research on alcohol use disorder often focuses on short-term relapse. However, factors influencing long-term relapse after sustained remission are largely unknown, despite its importance for ongoing recovery.
Pre-Arrest Diversion-To-Treatment for Adults with Substance Use Disorder: Health Outcomes and Predictors of Program Completion
Pre-arrest diversion programs offer an alternative to incarceration for drug-related crimes. These programs show promise in reducing re-arrests and improving health outcomes like overdose rates among participants.
Medication for opioid use disorder service delivery in carceral facilities: Update and summary report
Incarceration increases the risk of opioid overdose upon release due to decreased drug tolerance. Providing medication for opioid use disorder during incarceration significantly reduces overdose deaths.
Early Life Stress and Substance Use Disorders: Underlying Neurobiology and Pathways to Adverse Outcomes
Early life stress is a major public health concern impacting over half of adults. It significantly increases the risk for substance use disorders and other mental and physical illnesses, reducing lifespan.
Reward neurocircuitry predicts longitudinal changes in alcohol use following trauma exposure
This study explored how brain responses to reward in recently traumatized individuals predict changes in alcohol use. It also examined how these brain differences might vary between sexes.
Common neural patterns of substance use disorder: A seed-based resting-state functional connectivity meta-analysis
Substance use disorder (SUD) involves complex brain changes. Research identifies consistent functional connectivity abnormalities in brain reward circuits across different substances and addiction stages, linking these to impulsivity.
Prevalence of adverse childhood experiences among individuals in treatment for substance use disorder: Are ACE associated differently across type of abuse and quantity of consumption?
Adverse Childhood Experiences (ACE) are linked to many adult health issues. Studies find Indigenous populations, including those in Greenland, experience more ACE and are more likely to develop substance use disorders.
Recovery housing for substance use disorder: A systematic review
Substance use disorder (SUD) is a major global public health problem. Recovery housing offers vital long-term support, significantly improving recovery outcomes and cost-effectiveness for those seeking remission.
Redefining low-threshold buprenorphine access in an integrated mobile clinic program: Factors associated with treatment retention
A mobile clinic in Baltimore City expanded its low-barrier buprenorphine program by increasing time between visits and drug testing. These changes aimed to further reduce barriers to care for people who use drugs or experience homelessness.
Unravelling Polygenic risk and Environmental Interactions in Adolescent Polysubstance Use: a US Population-Based Observational Study
This study explores how genetic risks and environmental factors interact to influence adolescent polysubstance use. Findings aim to reveal underlying mechanisms and inform prevention strategies for substance use disorders.
Drug Addiction and Incarceration: A Call for Research and Transparency Among Prison-Based Substance Abuse Treatment programs
A significant majority of incarcerated individuals in the U.S. have a history of illicit drug use, and over half have diagnosable addictions. This highlights an urgent need for effective, transparent prison-based treatment programs.
Recruitment of Neuronal Populations in the Paraventricular Thalamus of Alcohol-Seeking Rats With Withdrawal-Related Learning Experience
The study identified neurons activated by environmental cues linked to alcohol in rats, showing different brain activity in dependent versus nondependent animals.
Alternative splicing in addiction
Addiction is a chronic disease marked by compulsive drug or alcohol use despite harmful outcomes, affecting many adults. Drugs of abuse all hijack the brain's reward circuit to increase dopamine, causing reinforcing effects.
Peripheral molecular and brain structural profile implicated stress activation and hyperoxidation in methamphetamine use disorder
This study investigated changes in blood molecules in people with methamphetamine use disorder. It found links between these molecular changes and brain structure alterations, potentially offering insights for treatment.