Brief of Center for Law, Brain & Behavior and Neuroscientists as Amici Curiae in Support of Plaintiff-Appellant Jwainus Perry
Center for Law, Brain & Behavior
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Summary

Amici argue that prolonged solitary confinement causes measurable structural and functional brain injuries, making the distinction between mental and physical harm obsolete and supporting constitutional protections for prisoners.

2022 | Federal Juristiction

Brief of Center for Law, Brain & Behavior and Neuroscientists as Amici Curiae in Support of Plaintiff-Appellant Jwainus Perry

Keywords nervous system; brain plasticity; harmful environments; mental injury; physical injury; solitary confinement; hippocampal shrinkage; social deprivation; chronic stress; brain changes

SUMMARY OF ARGUMENT

The human nervous system is fundamentally plastic: Brain structure, functions, and connections all change in response to intrinsic and extrinsic stimuli by reorganizing, even in adulthood. This malleability makes us deeply vulnerable to harmful environments. And those environments have impacts that are more than “merely” psychological; they change the brain itself. They amount to a physical injury. Legal policies which suggest mental injury is somehow not physical are subscribing to outdated scientific doctrine, especially with respect to solitary confinement.

Research has shown that the conditions of prolonged isolation, chronic emotional stress, and disrupted sleep endemic to solitary confinement are capable of causing adverse anatomical and functional changes in the brain, including in areas core to memory and learning (hippocampal shrinkage in chronic emotional stress and chronic sleep deprivation); in areas core to the social and emotional brain (social deprivation and atrophy in the posterior superior temporal sulcus, chronic sleep deprivation and damage to the insula and amygdala); in disordered immune and stress systems (impaired sleep increasing the presence of brain tau plaques, social isolation increasing amyloid and tau plaque presence and increasing cortisol levels); in functional disruptions related to emotional processing (chronic stress and post-traumatic stress disorder manifesting with hyperactivity in the amygdala), and shrinkage and dysfunction of areas of the brain core to learning, impulse control, reasoning, and social cognition (shrinkage of the medial prefrontal cortex and anterior cingulate cortex in PTSD, lowered connectivity in the corpus callosum and corona radiata in chronic stress, global reductions of cerebral blood flow tied to social isolation).

By any definition, such changes to the brain constitute physical injury.

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Summary

The human nervous system can change and adapt throughout a person's life. This ability allows the brain to reorganize its structure, functions, and connections based on experiences. This flexibility, while beneficial, also makes individuals susceptible to negative effects from harmful environments. These environments can cause more than just psychological problems; they can physically alter the brain. Such alterations are comparable to a physical injury. Legal frameworks that differentiate between mental and physical injuries, particularly concerning solitary confinement, rely on outdated scientific understanding.

Studies indicate that the conditions common in solitary confinement—extended isolation, ongoing emotional stress, and interrupted sleep—can lead to harmful physical and functional changes in the brain. For example, the hippocampus, vital for memory and learning, can shrink due to long-term emotional stress and lack of sleep. Regions of the brain involved in social and emotional processing, such as the posterior superior temporal sulcus, insula, and amygdala, can show damage or atrophy from social deprivation and chronic sleep loss. The immune and stress systems can also be negatively impacted; poor sleep can increase tau plaques in the brain, while social isolation can raise amyloid and tau plaques and elevate cortisol levels. Emotional processing can be disrupted, as seen in the overactivity of the amygdala in those experiencing chronic stress and post-traumatic stress disorder (PTSD). Furthermore, areas of the brain crucial for learning, impulse control, reasoning, and social understanding, such as the medial prefrontal cortex and anterior cingulate cortex, can shrink or become dysfunctional in PTSD. Chronic stress can also reduce connectivity in the corpus callosum and corona radiata, and social isolation can lead to a general decrease in blood flow to the brain.

These observed changes to brain structures and functions meet the criteria for a physical injury.

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Summary

The human nervous system is adaptable; its structure, functions, and connections change due to internal and external factors, even in adulthood. This adaptability makes individuals susceptible to harmful environments. These environments have more than just psychological effects; they alter the brain itself, causing what amounts to a physical injury. Legal policies that categorize mental injury as non-physical rely on outdated scientific understanding, particularly concerning solitary confinement.

Brain Changes Due to Isolation

Research indicates that prolonged isolation, chronic emotional stress, and disrupted sleep, which are common in solitary confinement, can lead to negative structural and functional changes in the brain. For instance, chronic emotional stress and sleep deprivation can shrink the hippocampus, an area important for memory and learning. Social deprivation can cause the posterior superior temporal sulcus, crucial for social and emotional processing, to atrophy, while chronic sleep deprivation can damage the insula and amygdala.

Immune System and Emotional Processing Impacts

Disruptions to the immune and stress systems also occur. Impaired sleep can increase brain tau plaques, and social isolation can increase amyloid and tau plaque presence while elevating cortisol levels. Functional disruptions related to emotional processing are also observed, with chronic stress and post-traumatic stress disorder (PTSD) showing hyperactivity in the amygdala.

Impact on Learning and Cognition

Furthermore, areas of the brain vital for learning, impulse control, reasoning, and social cognition can shrink and malfunction. PTSD can lead to shrinkage of the medial prefrontal cortex and anterior cingulate cortex. Chronic stress can reduce connectivity in the corpus callosum and corona radiata. Social isolation is also associated with global reductions in cerebral blood flow.

Conclusion on Physical Injury

These documented changes to the brain unequivocally represent a physical injury.

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Summary

The human brain can change and adapt throughout life. Its structure, functions, and connections all shift based on experiences from inside and outside the body. This ability to change makes individuals sensitive to difficult environments. These environments do more than just affect a person's thoughts and feelings; they physically alter the brain. Such changes can be considered a physical injury. Laws that suggest emotional harm is not physical are based on old scientific ideas, especially when it comes to solitary confinement.

Studies have shown that long periods of isolation, ongoing emotional stress, and lack of sleep commonly found in solitary confinement can cause harmful physical and functional changes in the brain. For example, areas important for memory and learning can shrink due to long-term emotional stress and sleep problems. Areas involved in social interaction and emotions can also shrink from lack of social contact, and sleep deprivation can damage parts of the brain like the insula and amygdala.

Additionally, the immune and stress systems can be negatively affected. Poor sleep can lead to more tau plaques in the brain, while social isolation can increase amyloid and tau plaques and raise cortisol levels. Emotional processing can also be disrupted; ongoing stress and PTSD can cause increased activity in the amygdala. Areas of the brain crucial for learning, self-control, reasoning, and understanding social cues can shrink and stop working properly, such as the medial prefrontal cortex and anterior cingulate cortex in PTSD. Chronic stress can also reduce connections in other brain areas, and social isolation can lead to less blood flow throughout the brain.

These kinds of changes to the brain clearly meet the definition of a physical injury.

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Summary

The human brain can change. It changes how it is built, what it does, and how its parts connect. These changes happen because of things inside and outside the body, even when a person is grown up. Because the brain can change, bad surroundings can really harm it.

These harmful surroundings do more than just make someone feel bad in their mind. They actually change the brain itself. This is like a physical injury. Laws that say mental harm is not physical harm are using old science, especially when talking about being held alone.

Studies show that being alone for a long time, having a lot of worry, and not sleeping well—all common in solitary confinement—can change the brain. These changes can be seen in how the brain is built and how it works. For example, parts of the brain important for memory and learning can get smaller. Parts of the brain for feelings and being social can also shrink or get damaged. The body's systems for fighting sickness and stress can get mixed up. Not sleeping enough can lead to bad things building up in the brain. Being alone can also raise stress chemicals.

Other problems include how the brain handles feelings, with some parts becoming too active. Parts of the brain important for learning, controlling actions, thinking clearly, and understanding others can shrink or not work well.

These kinds of changes to the brain are indeed physical injuries.

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Footnotes and Citation

Cite

Brief of Center for Law, Brain & Behavior and Neuroscientists as Amici Curiae in Support of Plaintiff-Appellant Jwainus Perry, Perry v. Spencer, No. 16-2444 (1st Cir. Mar. 11, 2022) (en banc)

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